Can Oxycodone Interact with my Anti-Depressant?

Prescription overdose and bad interactions account for thousands of deaths in the US every year. People are often less cautious about using prescription drugs, because these substances come from medical professionals, so their risks seem minimal. However, everyone reacts differently to drugs, whether the drug is prescription, over-the-counter or illicit.

All drugs are chemical substances, so even prescription drugs can cause adverse side effects. Many prescription drugs pose limited risks when abused, so users should take extreme care with any drug they take, including those that come from doctors.

Use Caution

Doctor talking with patient

It cannot be stressed enough how vital it is for patients to be straightforward with their medical professionals about drug usage.

As insignificant as it may seem to report taking a multivitamin or an occasional alcoholic beverage, sharing information like this can prevent serious side effects, negative interactions and the possibility of aggravating a health issue. Even food can react poorly with drugs, so, while it is important to share the drugs you use, users must also consider what they eat.

People should know what they are putting into their bodies, and a quick internet search can yield considerable information about a drug’s short-term and long-term effects, its risks of use, what drugs it interacts with, how the drug affects mood and energy and more.

Mixing Oxycodone with Antidepressants

Users should not mix oxycodone with many substances. Anti-depressants are common prescription drugs that treat several psychiatric conditions, such as anxiety disorders, depression and other conditions related to mood and behavior. There are several types of antidepressants, so there are several possible interactions that could occur when antidepressants are taken with oxycodone. Generally speaking, combing antidepressants with oxycodone can cause elevated blood pressure, dizziness, seizures, coma, impaired cognition and extremely depressive symptoms.

The following antidepressants poorly interact with oxycodone:
  • Isocarboxazid
  • Phenelzine
  • Rasagiline
  • Selegiline
  • Tranylcypromine.
  • Effexor
  • Citalopram (Celexa)
  • Zoloft (Sertraline)
  • Trazodone
  • Prozac
  • Not only can the interaction between oxycodone and antidepressants cause fatal side effects, but it can also cause one drug to block the other. Individuals struggling with depression, anxiety or other serious medical conditions may trigger severe episodes if they also take oxycodone, or if they notice that their medication is not working as it should. Individuals with depression put themselves at severe risk for suicide and other self-destructive tendencies when they tamper with their antidepressant dosage.

    Get Help

    If you have trouble with your medication or drug use, then call our toll-free, 24 hour helpline now at 877-345-8494. Our admissions coordinators can answer any questions you have, and they can provide you with all the information you need to find treatment. If you or a loved one is ready to find recovery, then get help today for your drug problem.

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